All functions

build_signature()

Build a prognostic gene signature from a survival cohort

cox_model()

Adjusted Cox proportional-hazards model for a signature

design_audit()

Audit candidate design covariates before differential-expression modeling

fetch_gse20685()

Fetch and process GSE20685 breast cancer cohort

generate_report()

Generate the rnaSentry analysis report

km_curve()

Kaplan-Meier survival analysis of a signature's risk groups

load_counts()

Validate and construct a SummarizedExperiment from count data

lock_signature()

Lock or unlock an rnaSentry signature

pca_audit()

PCA audit of expression data with optional batch association testing

plot_pca_audit()

Plot PCA scores from a pca_audit result

qc_explore()

Quality-control audit of a bulk RNA-seq SummarizedExperiment

run_rnaSentry()

Run the complete rnaSentry pipeline

sex_check()

Verify reported sex against inferred biological sex from expression

survival_parametric()

Parametric survival models for a signature's risk score

validate_external()

Validate a signature on an external cohort